Collaborative Center for Chemical and Biological Mass Spectrometry

Biological cluster mass spectrometry.

This article reviews the new physics and new applications of secondary ion mass spectrometry using cluster ion probes. These probes, particularly C(60), exhibit enhanced molecular desorption with improved sensitivity owing to the unique nature of the energy-deposition process. In addition, these projectiles are capable of eroding molecular solids while retaining the molecular specificity of mas...

Biomedical and biological mass spectrometry.

This review focuses on biological and biomedical mass spectrometry, and covers a selection of publications in this area included in the MEDLINE database for the period 1987-2001. Over the last 15 years, biological and biomedical mass spectrometry has progressed out of all recognition. The development of soft ionization methods, such as electrospray ionization and matrix-assisted laser desorptio...

Edgewood Chemical Biological Center

Edgewood Chemical Biological Center

Selective Reagents for Chemical Ionization Mass Spectrometry

Much of the power of chemical ionization mass spectrometry stems from the finding that the characteristics of the Cl mass spectrum produced is dependent on both the nature of the reagent gas and the type of ion-molecule reaction used to ionize the sample. Different structural information can be obtained with different reagent gases. As a consequence, it is possible to control the type and quant...